Human-machine interaction in the field of Advanced Manufacturing Technology(AMT) is tightly connected today to the different degrees through which human performance varies according to complex automated systems. Two factors are established in the Manufacturing, Services & User Experience literature: the design factors related to the interface, and the social characteristics of the system operation and organization. The role and impact of both the factors in several domains, including computer numerical control machines, industrial production lines and control room telemonitoring are discussed in this paper with the goal of exploring the challenges brought by production automation and to highlight on user interaction opportunities. Indeed the design of intelligent lines and machines are requiringth at the human-machine interfaces are able to encompass human supervisory control over automation, and to accomplish close, safe and dependable interaction between human and machine processing in a shared workspace. The availability of feedback and feed-forward control systems in the three domains being considered, i.e. computer numerical control machines, industrial production lines and control room telemonitoring, can be considered the crucial precondition for the evaluation of a reliable industrial human-machine-integration. This paper describes the research on ergonomics and the design of novel processing logics for system control and of a self-explanatory HMI to enhance system usability and interpretability and fostering adequate intervention when automated systems fail.